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ea0056gp34 | Adrenal cortex | ECE2018

Effects of replication of the physiological and non-physiological cortisol rhythm on insulin sensitivity in muscle: a molecular in vitro analysis on synchronized muscular cells

Negri Mariarosaria , Di Gennaro Gilda , Pivonello Claudia , Simeoli Chiara , Vennery Mary Anna , Barbagallo Federica , Iacuaniello Davide , De Martino Maria Cristina , Isidoro Andrea Maria , Colao Annamaria , Pivonello Rosario

Adrenal insufficiency is a rare endocrine disorder characterized by low levels of cortisol associated with increased mortality, also due to inadequate replacement therapy. The replacement with the thrice-daily immediate release hydrocortisone (IRH), in contrast to the once-daily modified-release hydrocortisone (MRH), more appropriately mimicking the physiological circadian rhythm of cortisol (PCRC), is associated with metabolic disorders, mainly due to the non-physiological pe...

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Effects of replication of the physiological and non-physiological cortisol rhythm on insulin sensitivity in muscle: a molecular in vitro analysis on synchronized muscular cells

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